sildenafil citrate in fetal growth restriction
نویسندگان
چکیده
background: pregnancies with early onset fetal growth restriction have poor perinatal outcome. sildenafil citrate (pde -5 inhibitor) as a vasodilator increases uteroplacental blood flow and potentiates fetal growth. case presentation: in this study, a case was examined and sildenafil was administered for her. it was found that sildenafil improved the uterine blood flow with a favorable fetal outcome at delivery. conclusion: sildenafil, as a vasodilator has emerged as a potential management option in the treatment of intra uterine growth retardation (iugr) and preeclampsia by later normalization in velocimetric profile.
منابع مشابه
Sildenafil Citrate in Fetal Growth Restriction
BACKGROUND Pregnancies with early onset fetal growth restriction have poor perinatal outcome. Sildenafil citrate (PDE -5 inhibitor) as a vasodilator increases utero-placental blood flow and potentiates fetal growth. CASE PRESENTATION In this study, a case was examined and Sildenafil was administered for her. It was found that Sildenafil improved the uterine blood flow with a favorable fetal o...
متن کاملSildenafil citrate and uteroplacental perfusion in fetal growth restriction
BACKGROUND To determine whether the phosphodiesterase type 5 inhibitor, Sildenafil citrate, affects uteroplacental perfusion. MATERIALS AND METHODS Based on a randomized double-blinded and placebo-controlled trial, forty one pregnant women with documented intrauterine growth retardation at 24-37 weeks of gestation were evaluated for the effect of a single dose of Sildenafil citrate on uteropl...
متن کاملSildenafil citrate for the management of fetal growth restriction and oligohydramnios
Fetal growth restriction (FGR) and preeclampsia are the major causes of neonatal morbidity and mortality, which affect up to 8% of all pregnancies. The pathogenesis in FGR is an abnormal trophoblastic invasion leading to compromised uteroplacental circulation. However, in spite of this understanding and identification of high-risk patients, the management options are limited. There are some new...
متن کاملSildenafil Citrate Increases Fetal Weight in a Mouse Model of Fetal Growth Restriction with a Normal Vascular Phenotype
Fetal growth restriction (FGR) is defined as the inability of a fetus to achieve its genetic growth potential and is associated with a significantly increased risk of morbidity and mortality. Clinically, FGR is diagnosed as a fetus falling below the 5(th) centile of customised growth charts. Sildenafil citrate (SC, Viagra™), a potent and selective phosphodiesterase-5 inhibitor, corrects ex vivo...
متن کاملSildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model.
Preeclampsia and fetal growth restriction are responsible for the majority of maternal and perinatal morbidity and mortality associated with complicated pregnancies. Although their etiologies are complex and multifactorial, both are associated with increased uterine artery resistance. Sildenafil citrate is able to rescue the dysfunction observed ex vivo in uterine arteries of women with preecla...
متن کاملEffect of L-arginine and sildenafil citrate on intrauterine growth restriction fetuses: a meta-analysis
BACKGROUND Intrauterine growth restriction (IUGR) is associated with perinatal morbidity and mortality. Several clinical trials have reported L-arginine and sildenafil citrate had effect on intrauterine growth restriction fetuses. A meta-analysis of available randomized controlled trials (RCTs) was conducted to investigate the effects of L-arginine and sildenafil citrate on major clinical outco...
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عنوان ژورنال:
journal of reproduction and infertilityجلد ۱۵، شماره ۳، صفحات ۱۶۸-۱۷۰
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